CreERT2 Zoo


The CreERT2 Zoo mouse resource from the Institut Clinique de la Souris (ICS) is a collection of about 50 cell specific Tamoxifen inducible Cre driver lines (available as alive animals and/or frozen materials). All lines are freely available to the scientific community with a materiel transfert agreement (MTA). To request a line please contact us by email at ics@igbmc.fr.

Targeted system Targeted cells Gene name promoter Reference Construct type Mutation types Strain of origin Genetic background State
All Systems Ubiquitous Ppm1a-CreERT2 mPpm1a MGI:99878 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N2 Live Mice
Adipose Tissue Pre-adipocytes Dlk1-CreERT2 mDlk 1 MGI:94900 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N4 Live Mice
Adipose Tissue Adipocytes Adipoq-CreERT2 mAdipoq MGI:106675 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Adipose Tissue Brown adipose tissue adipocytes Ucp1-CreERT2 mUcp1 MGI:98894 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Adipose Tissue Adipocytes Fabp4-CreERT2 mFabp4 MGI:88038 BAC Transgenic Pronuclear injection FVB/N   Live Mice
Adipose Tissue Adipocytes AP2-CreERT2 Ap2 MGI:88038 Plasmid Transgenic knock-in 129S2/SvPas C57BL/6N N3 / N4 Live Mice
Central Nervous System Dopaminergic neurons Slc6a3-CreERT2 mSlc6a3 MGI:94862 BAC Transgenic Pronuclear injection C57BL/6J C57BL/6N N4 Live Mice
Central Nervous System Serotonergic neurons Slc6a4-CreERT2 mSlc6a4 MGI:96285 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Central Nervous System Purkinje Cells Pcp2-CreERT2 mPcp2 MGI:97508 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N4 Live Mice
Central Nervous System Neural progenitors Nes-CreERT2 mNes MGI:101784 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Central Nervous System Mature neurons Eno2-CreERT2 mEno2 MGI:95394 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N2 Live Mice
Central Nervous System Mature neurons Nefl-CreERT2 mNefl MGI:97313 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N4 Live Mice
Central Nervous System Hippocampal neurons (CA1) Camk2a-CreERT2 mCamk2a MGI:88256 Plasmid Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N4 Live Mice
Central Nervous System Neural stem cells Sox2-CreERT2 mSox2 MGI:98364 BAC Transgenic Pronuclear injection C57BL/6N C57BL/6N N2 Live Mice
Digestive tract Epithelial cells of intestinal crypts Vil1-CreERT2 mVill MGI:98930 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Digestive tract Endocrine cells in the gastric mucosa Ghrl-CreERT2 mGhrl MGI:1930008 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Urinary System Epithelial cells of renal proximal tubules Kap-CreERT2 mKap MGI:96653 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Mammary Gland Cells of mammary gland MMTV-CreERT2 MMTV   Plasmid Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N4 Live Mice
Mammary Gland Epithelial cells of mammary gland Wap-CreERT2 mWAP MGI:1915471 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Muscles skeletal muscle cells Tnni2-CreERT2 mTnni2 MGI:105070 BAC Transgenic Pronuclear injection C57BL/6J C57BL/6N N4 Live Mice
Digestive Glands Beta-cells of pancreatic islets Ins1-CreERT2 mIns1 MGI:96572 Plasmid Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Digestive Glands Beta-cells of pancreatic islets Ins1-CreERT2 mIns1 MGI:96573 BAC Transgenic Pronuclear injection 75%C57BL/6J - 25% SJL/J C57BL/6N N3 Live Mice
Digestive Glands Pancreatic Alpha cells Gcg-CreERT2 mGcg MGI:95674 Plasmid Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Digestive Glands Pancreatic Alpha cells Gcg-CreERT2 mGcg MGI:95675 BAC Transgenic Pronuclear injection C57BL/6J C57BL/6N N4 Live Mice
Digestive Glands Exocrine pancreatic cells Ela1-CreERT2 mEla1   BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Male Reproductive System Spermatocytes Pgk2 CreERT2 mPgk2 MGI:97563 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Female Reproductive System Oocytes Zp3-CreERT2 mZp3 MGI:99215 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N4 Live Mice
Integumental System Suprabasal layer of the skin Krt10CreERT2 mKrt10 MGI:96685 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Integumental System Keratinoyctes of the skin basal layer Krt5-CreERT2 mKrt5 MGI:96702 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Integumental System Keratinoyctes of the skin basal layer Krt14-CreERT2 mKrt14 MGI:96688 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Cardiovascular System Cardiomyocytes Myh6-CreERT2 mMyh6 MGI:97255 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Skeletal System Osteoclasts Acp5-CreERT2 mAcp5 MGI:87883 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Skeletal System Osteoclasts Col1a1-CreERT2 mColla1 MGI:88467 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Skeletal System Osteoblasts Bglap1-CreERT2 mBglap1 MGI:88156 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N2 / N3 Live Mice
Immune System Lymphocytes Lck-CreERT2 mLck MGI:96756 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Immune System Megakarocytes Cxcl4-CreERT2 mCxc14 MGI:1888711 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N2 Live Mice
Immune System Megakarocytes Gp1ba-CreERT2 mGp1ba MGI:1333744 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Immune System Macrophages Cd68-CreERT2 mCD68 MGI:88342 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N4 Live Mice
Immune System Macrophages Lyzs-CreERT2 mLyzs MGI:96897 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
Immune System T cells Cd4-CreERT2 mCD4 MGI:88335 BAC Transgenic Pronuclear injection FVB/N C57BL/6N N3 Live Mice
Immune System B cells CD19-CreERT2 hCD19 GeneID: 930 BAC Transgenic Pronuclear injection 50%C57BL/6J - 50% SJL/J C57BL/6N N3 Live Mice
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Director : Dr. Yann Hérault