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• Phenotyping service offer

Phenotyping service offer

• At a glance
• ICS' phenotyping capacities
• ICS' added value
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Our mission is to assist investigators in their experimental design by providing an extensive baseline phenotypic profile of mice.

Several approaches can be propose, according to our established SOPs and our expertise:

• • Comprehensive standardized first line protocol
• • Customized phenotyping protocol
• • Pharmaco-phenotyping (Pharmacology, pharmacokinetic, lead optimization toxicology screening)
• • Disease focused approach :

Therapeutic area
Metabolism
Disease	Suggested first line tests (to pick)	Additional assays	Download
Diabetes, obesity & metabolic syndrome	Glucose tolerance, insulin sensitivity, lean and fat composition, glycemia, lipemia, hepatic enzymes and endocrinology	Diet induced obesity challenge, food restriction, glucose clamp, energy expenditure, food and water consumption, feces energy content, adaptative thermogenesis, exercise test
Malabsorbtion & other gastrointestinal disorders	Food and water consumption, intestinal transit, feces energy content, lipid absorbtion, blood chemistry	Necropsy, organ weight and targeted histology (Also see Crohn's disease)	Available soon
Nephrology
Disease	Suggested first line tests (to pick)	Additional assays	Download
Renal function	Urinary analysis, creatin clearance, proteinemia, albuminemia, renin activity, aldosterone levels	Echocardiography, non invasive blood pressure. Necropsy, organ weight and targeted histology	Available soon
Cardiovascular
Disease	Suggested first line tests (to pick)	Additional assays	Download
Atherosclerosis	Cholesterol-enriched diet challenge, blood and tissue lipid, blood and aortic cholesterol levels, atheromatous plaques analyze on aorta	Necropsy, organ weight and targeted histology
Hypertension	Non invasive blood pressure & heart rate, echocardiography, renin activity, aldosterone levels	Blood pressure telemetry, model of hypertension. Necropsy, organ weight and targeted histology. Renal function
Heart failure, arythmia, cardio-myopathy	Non invasive blood pressure & heart rate, echocardiography, electrocardiography, heart fibrosis and histology	Telemetry, intraventricular pressure, angiotensin II induced hypertension and cardiac remodeling. Necropsy, organ weight and targeted histology
Thrombosis, coagulation	Non invasive blood pressure & heart rate, echocardiography, electrocardiography, heart fibrosis and histology	Telemetry, intraventricular pressure, angiotensin II induced hypertension and cardiac remodeling. Necropsy, organ weight and targeted histology
Respiratory
Disease	Suggested first line tests (to pick)	Additional assays	Download
Asthma & respiratory diseases	Ovalbumin, model of asthma,plethysmograhy (spontaneous or metacholine induced airway responsivness), brochoalveolar liquide analyze, immunoglobulin levels and lung histology	COPD, pulmonary fibrosis. Necropsy, organ weight and targeted histology
Inflammation
Disease	Suggested first line tests (to pick)	Additional assays	Download
Immunology	FACS analysis, cytokine, immunoglobulins and basic hematology	Ovalbumin & lipopolysaccharide challenges. Necropsy, organ weight and targeted histology	Available soon
Crohn's disease & inflammatory intestinal diseases	Gut inflammation score, hemoccult, disease severity score	Blood chemistry, hematology. Necropsy, organ weight and targeted histology	Available soon
Psychiatry
Disease	Suggested first line tests (to pick)	Additional assays	Download
Mood disorders: Anxiety and depression	Open field, elevated plus maze, light/dark test, tail suspension test, forced swim test	Sucrose preference test. Targeted histology
Schizophrenia	Acoustic startle and prepulse inhibition	Cross-modal prepulse inhibition. Targeted histology	Available soon
Neurology
Disease	Suggested first line tests (to pick)	Additional assays	Download
Alzheimer & memory related diseases	Y-Maze, Moris water maze, object recognition, fear conditioning	Scopolamine-induced amnesia, neurogenesis. Target histology
Parkinson disease & Huntington disease	SHIRPA, rotarod, grip test, traction reflex test, beam walking	Morag. Targeted histology.
Sleep disorders	Circadian activity	Targeted histology.
Motor neuron disease & myopathies	SHIRPA, rotarod, grip test, traction reflex test, beam walking, exercise test, exercise, EMG	Lean composition. Necropsy, organ weight and targeted histology
Acute pain	Tail flick, hot plate, formalin and shock threshold	Targeted histology
Epilepsy	Pentylen-tetrazol induced seizure	Auditive induced seizure, ECG. Targeted histology
Vision	Slit lamp imaging, electroretinogram	Fundus imaging and angiography
Audition	Auditory brain stem response	Prepulse inhibition test, clic box
Development & growth
Disease	Suggested first line tests (to pick)	Additional assays	Download
Development & growth	Window of lethality, histological characterization of embryonic and perinatal defects, dysmorphology screen, DEXA-scan	Necropsy, organ weight and targeted histology. Metabolic screen	Available soon

To access to a complete list of assays per physiological area, click here.