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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., Thomas G.
Nature 2004 Sep 9;431(7005):200-5

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Watanabe M., Houten S.M., Wang L., Moschetta A., Mangelsdorf D.J., Heyman R.A., Moore D.D., Auwerx J.
J Clin Invest 2004 May;113(10):1408-18

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Cardiovascular and survival effects of sympatho-inhibitors in adriamycin-induced cardiomyopathy in rats.

Thomas L, Bellmont S, Christen MO, La Roche B, Monassier L.
Fundam Clin Pharmacol 2004 Dec;18(6):649-55

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Cre-mediated conditional gene targeting to understand liver functions

Metzger D., Chambon P
Drug Discovery Today: Disease Models 2004 ;1(3):229-234

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Current mouse models for studying cardiac dysfunctions: technical and imaging aspects

Monassier L, Theodoropoulos C, Sandler R, Constantinesco A.
Drug Discovery Today 2004 ;1():235-241

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Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model

Helmlinger D., Abou-Sleymane G., Yvert G., Rousseau S., Weber C., Trottier Y., Mandel J.L., Devys D.
J Neurosci 2004 Feb 25;24(8):1881-7

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Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

Schuler M., Dierich A., Chambon P., Metzger D.
Genesis 2004 Jul;39(3):167-72

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Expression of the liver X receptor alpha and beta in embryonic and adult mice

Annicotte J.S., Schoonjans K., Auwerx J.
Anat Rec 2004 Apr;277A(2):312-6

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Idebenone delays the onset of cardiac functional alteration without correction of Fe-S enzymes deficit in a mouse model for Friedreich ataxia

Seznec H., Simon D., Monassier L., Criqui-Filipe P., Gansmuller A., Rustin P., Koenig M., Puccio H.
Hum Mol Genet 2004 May 15;13(10):1017-24

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Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice

Fajas L., Annicotte J.S., Miard S., Sarruf D., Watanabe M., Auwerx J.
J Clin Invest 2004 May;113(9):1288-95

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Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts

Jaffre F., Callebert J., Sarre A., Etienne N., Nebigil C.G., Launay J.M., Maroteaux L., Monassier L.
Circulation 2004 Aug 24;110(8):969-74

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Knockout mouse models in pain research

Dierich A., Kieffer B.L.
Methods Mol Med 2004 ;99():269-300

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Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells

Mascrez B., Ghyselinck N.B., Watanabe M., Annicotte J.S., Chambon P., Auwerx J., Mark M.
Embo Rep 2004 Mar;5(3):285-290

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LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

Fayard E., Auwerx J., Schoonjans K.
Trends Cell Biol 2004 May;14(5):250-60

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Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene

Yan K.P., Dolle P., Mark M., Lerouge T., Wendling O., Chambon P., Losson R.
Gene 2004 Jun 9;334():3-13

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Mouse functional genomics requires standardization of mouse handling and housing conditions

Champy M.F., Selloum M., Piard L., Zeitler V., Caradec C., Chambon P., Auwerx J.
Mamm Genome 2004 Oct;15(10):768-83

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Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction

Mark M., Yoshida-Komiya H., Gehin M., Liao L., Tsai M.J., O'Malley B.W., Chambon P., Xu J.
Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4453-8

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Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Imai T, Takakuwa R, Marchand S, Dentz E, Bornert JM, Messaddeq N, Wendling O, Mark M, Desvergne B, Wahli W, Chambon P, Metzger D.
Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4543-7

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Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm

Cock T.A., Houten S.M., Auwerx J.
Embo Rep 2004 Feb;5(2):142-7

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PU.1 determines the self-renewal capacity of erythroid progenitor cells

Back J., Dierich A., Bronn C., Kastner P., Chan S.
Blood 2004 May 15;103(10):3615-23

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Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium

Mori M., Metzger D., Picaud S., Hindelang C., Simonutti M., Sahel J., Chambon P., Mark M.
Am J Pathol 2004 Feb;164(2):701-10

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Retinoic acid signalling in the development of branchial arches

Mark M., Ghyselinck N.B., Chambon P.
Curr Opin Genet Dev 2004 Oct;14(5):591-8

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Synergy between LRH-1 and beta-Catenin Induces G(1) Cyclin-Mediated Cell Proliferation

Botrugno O.A., Fayard E., Annicotte J.S., Haby C., Brennan T., Wendling O., Tanaka T., Kodama T., Thomas W., Auwerx J., Schoonjans K.
Mol Cell 2004 Aug 27;15(4):499-509

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The European dimension for the mouse genome mutagenesis program

Auwerx J., Avner P., Baldock R., Ballabio A., Balling R., Barbacid M., Berns A., Bradley A., Brown S., Carmeliet P., Chambon P., Cox R., Davidson D., Davies K., Duboule D., Forejt J., Granucci F., Hastie N., De Angelis M.H., Jackson I., Kioussis D., Kollias G., Lathrop M., Lendahl U., Malumbres M., Von Melchner H., Muller W., Partanen J., Ricciardi-Castagnoli P., Rigby P., Rosen B., Rosenthal N., Skarnes B., Stewart A.F., Thornton J., Tocchini-Valentini G., Wagner E., Wahli W., Wurst W.
Nat Genet 2004 Sep;36(9):925-7

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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

El Marjou F., Janssen K.P., Hung-Junn Chang B., Li M., Hindie V., Chan L., Louvard D., Chambon P., Metzger D., Robine S.
Genesis 2004 Jul;39(3):186-93

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