The Institute
- IBiSA
- ISO 9001/2008 in progress
- 7 years of partnership with pharmaceutical companies
- More than 250 mutagenesis or phenotyping projects per year
- Partner in 14 EU funded projects since 2002
- 110 staff members
The Institut Clinique de la Souris - ICS (Mouse Clinical Insitute - MCI) is a research infrastructure of excellence for translational research and functional genomics. Founded in 2002 by Pierre Chambon, operated by Inserm, CNRS and the University of Strasbourg and supervised by GIE-CERBM, it provides a comprehensive set of specialised services to academic and industrial users and is a major player in the European post-genomics era programs. The close interaction with the IGBMC strongly contributes to the development and design of new techniques and functional assays.
The ICS combines the capacity of generating mutant mice on a large scale with a high-throughput and comprehensive phenotypic analysis of the animals. The Institute's phenotyping platforms are adapted for the study of genetically engineered mouse models and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.
The three highly interactive departments Genetic Engineering and Model Validation, Phenotyping and Mouse Supporting Services generate approximately 200 genetically modified mice per year. Phenotypic analysis cover hematology, immunology, inflammation, blood chemistry, metabolism, cardiovascular respiratory, sensory organs, cognition, learning, behavior, reproduction, morphology, ...
The services of the ICS will ultimately help the scientific community to use the mouse to develop a complete functional annotation of the human genome and to employ this to better understand human diseases and their underlying physiological and pathological basis.
With the new project PHENOMIN (part of the call for projects called National Infrastructures in Biology and Health), the goal of the ICS is to give birth to a national infrastructure specialized in development, analysis and conservation of mice models. This project federates teams of excellence in mouse genetics (Strasbourg, Orléans, Marseille and Villejuif).
