Metabolic exploration
Energy metabolism
Glucose homeostasis
Intestinal function
- Metabolic cage: feces production (see Energy metabolism)
- Bomb calorimeter: evaluation of gross energy in feces
- Intestinal transit evaluation: in progress
Renal function
- Metabolic cage: urine collection for clearance measurement
- Spot urine collection for metabolite analysis
Energy challenges & models
- Exercise test
- Cold exposure
- Food restriction and refeeding
- Diet intervention or/and pharmacological intervention
The metabolic analysis of the mice could be combined with clinical assessments, by performing biochemical analysis in blood, plasma, urine and tissues (i.e, lipid and cholesterol content, glycogen content...) and by performing autopsy of the animal at the end of phenotyping study with several tissue collections (i.e, histology, mRNA anlaysis, protein analysis...).