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  • Advanced Histological Stainings at ICS

    ICS is proud to offer new capabilities for histological examinations, the Masson’s trichrome and the Russell-Movat pentachrome stains. 

    Both these stains are excellent means for visualizing collagen deposits (fibroses), but with the Movat’s pentachrome stain one can also differentiate elastic fibres, muscle, mucin, and fibrin.  For detailed histological examinations or high quality images for publication, consider these stains to improve your understanding and impress your colleagues. 

     

    Left picture: Masson trichrone staining of a heart with massive fibrosis (in blue)

    Right picture: Movat Pentachrome Phamini modification: collagen is stained by light green

  • Model Creation Services

    Charles River Europe has joined forces with PHENOMIN-ICS, a scientific leader in functional genomics, to deliver a complete solution for mouse and rat model creation.

  • Neuromuscular Phenotyping

    ICS is proud to offer novel assays for assessment of neuromuscular and muscular defects as part of our phenotyping. 

    Mouse Reaching and Grasping (MoRaG) assay as well as automated gait (DigiGait) analysis now complement our existing grip strength, rotorod, and beam walking assays.  Along with  isolated muscular strength assays that are coming soon, we provide excellent capabilities to assess neuromuscular and muscular defects in your animals.  

  • Mammalian gene function analysis

    The European Mouse Disease Clinic was the first mouse genetics project of its kind, and set the stage for an international effort to investigate the functions of 20,000 mammalian genes.

    Sequencing the human genome was an enormous achievement, but it was just the start. The functions of most genes still remain unknown, so the next big challenge is to be able to understand how this DNA code makes us who we are. What exactly do these genes do, and how do faults in our genes lead to disease?

    One of the best places to start to understand our own genetics is by investigating the mouse genome, since mice share over 90% of our genes. The European Mouse Disease Clinic (EUMODIC), a consortium set up in 2007, brought together scientists from many nations to investigate the functions of over 300 genes in mice. Over half of these genes had no previously known role. The consortium’s findings have now been published in Nature Genetics.

    EUMODIC was the first step along the way to creating a database of all mouse gene functions, a vision now being realised by the International Mouse Phenotyping Consortium (IMPC). Covering 20,000 genes, carried out by 18 centres from across the globe and estimated to take 10 years, this enormous research endeavour is taking the groundwork established by EUMODIC to an entirely new level. 

  • Direct blastocyst genotyping

    Validate your cryopreserved line by direct blastocyst genotyping

    Direct blastocyst genotyping is now available for your lines at PHENOMIN-ICS. Using this method instead of conventional post-implantation genotyping protocols leads to significant reductions in animal welfare concerns, processing time, technical requirements, and cost. For details, see the publication we coauthored in Transgenic Res (F. Scavizzi et al, 2015).

  • 1st Prize of ComTech Photo contest

    Members of PHENOMIN-ICS mouse supporting services won the 2016 ComTech photo contest.

    The picture "SHIVA, God of animal facility" will be published in the AFSTAL magazine ! Congratulations !

    Credits: Animal Facility/PHENOMIN-ICS

Order your own rat model !

Events

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Jun. 10, 2016 Workshop


Jun. 13 - Jun. 16, 2016 Congress


Jun. 27 - Jun. 30, 2016 Training course


Jun. 29 - Jul. 01, 2016 Congress


Sep. 03 - Sep. 07, 2016 Congress

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