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The Nuclear Receptor Zoo mouse resource from the Institut Clinique de la Souris (ICS) is a collection of Nuclears Receptors and Coregulators genetically engineered models, either as conditional or total knock-out mutant (available as live animals and/or frozen materials).

The mouse lines described here are available for academic users under MTA agreement and distribution fees. The fees for these animals are calculated on cost recovery basis and are used to recover animal husbandry and stock replacement costs (fees do not include the costs for shipping the material from the ICS facility to the recipient's institution.).

Distribution fees

Live Mice (6-7 weeks of age, 2-3 Breeding pairs): 3200 € 
Cryopreserved embryos (about 50 embryos in 2 straws): 1600 €

In most of the case only heterozygous carrier has been used for archiving and thus the distributed materiel may contain carrier (mutant or transgenic) and control (not mutant or not transgenic) embryos or gametes. ICS offers additional breeding services to e.g. generate cohorts of homozygous mutants. A quotation for such a service is available upon request.

Please note that all the lines are not specifically maintained for distribution. We thus cannot guaranty immediate shipment of live animals you requested. Once a request of interest is received, you will be contacted by email within a week to give you an up-to date availability of the requested line.

More Details on the restrictions, on PI and on the distribution is available upon request.

Gene name Other gene name Reference Mutation types Strain of origin Genetic background Status
CARa NR1I3 MGI:1346307 knock-out 129S2/SvPas C57BL/6J N3 Frozen Embryos
CARa NR1I3 MGI:1346307 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
COUP-TF2 NR2F2 MGI:1352452 conditional knock-out 129S2/SvPas C57BL/6J N4 Frozen Embryos
EAR2 NR2F6 MGI:1352453 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
EAR2 NR2F6 MGI:1352453 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
ERR1 NR3B1 MGI:1346831 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
ERR1 NR3B1 MGI:1346831 knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
ERR2 NR3B2 MGI:1346832 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
ERR2 NR3B2 MGI:1346832 knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
ERR3 NR3B3, ERRg MGI:1347056 conditional knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
ERR3 NR3B3, ERRg MGI:1347056 knock-out 129S2/SvPas C57BL/6J N9 Frozen Embryos
FXRa NR1H4, RIP14, HRR1 MGI:1352464 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
FXRa NR1H4, RIP14, HRR1 MGI:1352464 knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
GCNF1 NR6A1, RTR MGI:1352459 conditional knock-out 129S2/SvPas C57BL/6J N4 Frozen Embryos
GCNF1 NR6A1, RTR MGI:1352459 knock-out 129S2/SvPas C57BL/6J N9 Frozen Embryos
GR NR3C1 MGI:95824 knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
GR NR3C1 MGI:95824 conditional knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
HNF4a NR2A1, HNF4 MGI:109128 knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
HNF4a NR2A1, HNF4 MGI:109128 conditional knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
HNF4g NR2A2 MGI:1353604 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
HNF4g NR2A2 MGI:1353604 knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
LXRa NR1H3, RLD1, LXR MGI:1352462 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
LXRa NR1H3, RLD1, LXR MGI:1352462 knock-out 129S2/SvPas C57BL/6J N10 Frozen Embryos
LXRb NR1H2, UR, OR-1, NER1, RIP15 MGI:1352463 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
LXRb NR1H2, UR, OR-1, NER1, RIP15 MGI:1352463 conditional knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
MR NR3C2 MGI:99459 conditional knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
MR NR3C2 MGI:99459 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
Ncor1 Rip13 MGI:1349717 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
Ncor1 Rip13 MGI:1349717 conditional knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
Ncor2 SMRT, N-CoR MGI:1337080 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
Ncor2 SMRT, N-CoR MGI:1337080 knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
PGC1-b MGI:2444934 conditional knock-out C57BL/6N C57BL/6N Frozen Embryos
PGC1-b MGI:2444934 knock-out C57BL/6N C57BL/6J N3 Frozen Embryos
PNR NR2E3 MGI:1346317 conditional knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
PNR NR2E3 MGI:1346317 knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
PPARa NR1C1 MGI:104740 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
PPARa NR1C1 MGI:104740 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
PR NR3C3 MGI:97567 conditional knock-out 129S2/SvPas C57BL/6J N4 Frozen Embryos
PR NR3C3 MGI:97567 knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
PXR NR1I2 MGI:1337040 knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
PXR NR1I2 MGI:1337040 conditional knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
RAP-250 AIB3, PRIP MGI:1929915 knock-out 129S2/SvPas C57BL/6J N12 Frozen Embryos
RAP-250 AIB3, PRIP MGI:1929915 conditional knock-out 129S2/SvPas C57BL/6J N10 Frozen Embryos
REA Bap MGI:102520 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
REA Bap MGI:102520 conditional knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
RevErba NR1D1, EAR1, EAR1A MGI:2444210 conditional knock-out 129S2/SvPas C57BL/6J N10 Frozen Embryos
RevErba NR1D1, EAR1, EAR1A MGI:2444210 knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
RevErbb NR1D2, EAR1b, BD73, RVR, HZF2 MGI:2449205 conditional knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
RevErbb NR1D2, EAR1b, BD73, RVR, HZF2 MGI:2449205 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
RORa NR1F1, RZRa MGI:104661 knock-out 129S2/SvPas C57BL/6J N4 Frozen Embryos
RORa NR1F1, RZRa MGI:104661 conditional knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
RORb NR1F2, RZRb MGI:1343464 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
RORb NR1F2, RZRb MGI:1343464 conditional knock-out 129S2/SvPas C57BL/6J N10 Frozen Embryos
RORg NR1F3, TOR MGI:104856 conditional knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
RORg NR1F3, TOR MGI:104856 knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
RXRg NR2B3 MGI:98216 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
RXRg NR2B3 MGI:98216 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
SF1 NR5A1 MGI:1346833 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
SF1 NR5A1 MGI:1346833 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
SHP NR0B2 MGI:1346344 conditional knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
SHP NR0B2 MGI:1346344 knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
SRC3 P/CIP MGI:1276535 knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
SRC3 P/CIP MGI:1276535 conditional knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
TLX NR2E1 MGI:1100526 knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
TLX NR2E1 MGI:1100526 conditional knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
TR4 NR2C2, TR2b, TAK1 MGI:1352466 conditional knock-out 129S2/SvPas C57BL/6J N8 Frozen Embryos
TR4 NR2C2, TR2b, TAK1 MGI:1352466 knock-out 129S2/SvPas C57BL/6J N6 Frozen Embryos
Trap220 PBP, DRIP205 MGI:1100846 knock-out 129S2/SvPas C57BL/6J N5 Frozen Embryos
Trap220 PBP, DRIP205 MGI:1100846 conditional knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
TRb NR1A2, c-erbA-2, THRB MGI:98743 knock-out 129S2/SvPas C57BL/6J N4 Frozen Embryos
TRb NR1A2, c-erbA-2, THRB MGI:98743 conditional knock-out 129S2/SvPas C57BL/6J N4 Frozen Embryos
Trip-15 Alien MGI:1330276 conditional knock-out 129S2/SvPas C57BL/6J N7 Frozen Embryos
Trip-15 Alien MGI:1330276 knock-out 129S2/SvPas C57BL/6J N9 Frozen Embryos

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