To secure and to control the huge amount of data generated by all the operations, a Laboratory Information Management System (LIMS) has been developed. The ICS has a dedicated team of 4 people to manage its information system. The team has developed modern, web-based applications to capture process and analyse all relevant data of the ICS. These databases cover major activities (genetic engineering, animal facility, phenotyping), as well as transversal fields such as quality control.
CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models. Now we can offer the generation of knock-out models though direct injection into fertilized mouse oocytes of CRISPR sgRNA and Cas9 mRNA. This approach allows to obtain models in shorter timelines and with reduced costs compared to gene targeting by homologous recombination in ES cells.
Download the FAQs in PHENOMIN's resources web page: CRISPR guidelines.
Listing established thanks to the great work from the Hopkins Institute
Brain Atlas Projects
JAX online resources