The Phenotyping department provides comprehensive, standardized or advanced, customized characterization of gene function in mouse models. We offer state-of-the-art services, consultancy and equipment for identification of anatomical, physiological, and behavioral phenotypes. We help our clients better understand the function of genes, basic mechanisms of biology, pathophysiology of diseases, to identify and validate new drug targets and to perform risk assessment in drug development. Currently, the department consists in 24 experienced biologists (8 PhDs and 16 technicians/engineers) within 6 cooperating disciplines for superior clinical characterization.
For meaningful scientific interpretation of histopathological data through analysis of large cohorts of mice, we recommend, 24 mice per age group (i.e., number used in systematic clinical tests). However, as it takes several hours of technician time to collect, process and stain the tissues of a single mouse, economical aspects must be taken into account. Hence, we commonly recommend the following as a more economical phenotyping strategy:
ICS proposes a first-line panel of blood analyses in order to give first insights into clinical chemistry, hematology and endocrinology. This provides clients a rapid and economical first insight regarding general health and potential aberrant pathways for their mouse model.
Broad general phenotyping (Metabolism, cardiology, bone...) through EMPReSS program
Broad general phenotyping (Behavior, CNS, sensory system...) through EMPReSS program