The 20th anniversary of the ICS (Institut Clinique de la Souris) coincides with the 20th anniversary of the sequencing of the mouse genome!
Over the past 20 years, ICS has made significant contributions to the study of gene function and to innovations that have transformed the research landscape in this field. On this occasion, the entire ICS staff invites you to participate in meetings, exchanges, visits, workshops, webinars and debates.
We hope to give everyone the opportunity to exchange, including meeting our users and our partners and celebrate this anniversary together.
The objective of this conference is to open the discussion on the concepts discovered thanks to the studies conducted with the mouse and rat model organisms. By bringing together these internationally renowned scientists, working in academia and in the private sector, we will be able to share a set of discoveries that are crucial for basic research, biomedical research and therapeutic innovation.
Webinar user's cases : recurrent short meeting, held online, from Jan. 2022 to share mouse and rat model experience with you.
Spring 2022: special event to share with the industrials and compagnies from the Innovation Park of Illkirch
Nov. 2022: this month marks the official ceremony, organized on site over 2 days, Nov. 17-18th, at the Innovation park of Illkirch and the IGBMC auditorium (Illkirch, France) - Save the date !
Several satellites meetings and special events: As the events are prepared
The user webinars are an opportunity to present our contribution to our clients' research work and to discuss the interest of their research work, the mouse models and the technologies used to answer their scientific questions. Each webinar will allow two of our users to speak and testify in this sense.These meetings will be held on Tuesdays online, every month or so, and you are all invited to attend and contributes to the discussion.
Aspasia PLOUBIDOU, PhD, Associated Group Leader, Leibniz Institute on Aging, Jena, Germany
Partner with iCS in EU consortium project "CanPathPro"
Title of the presentation: CANPAthPro, Predictive Cancer Pathway Modelling
Publications made with iCS: Isolation, ‘omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells bioRxiv 2021
Frédéric SIMONIN PhD, CNRS DR1, Leader of team « GPCRs in Pain and Inflammation », France
Title of the presentation : GPR103-26RFa is a new pronociceptive system involved in neuroadaptive changes associated with chronic opioid administration
Summary: The phenotyping of knockout animals for the five RFamide receptors allowed us to identify GPR103 as a novel pronociceptive system involved in adaptations associated with chronic opioid administation. We further identify a selective antagonist of this receptor and made the proof of concept that pharmacological blockade of GPR103 can limit the development of opioid side effects.
Recent publications made with ICS :
- RF313, an orally bioavailable NPFF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents. Elhabazi K., Humbert J.-P., Bertin I., Quillet R., Utard V., Schmitt M., Bourguignon J.-J., Laboureyras E., Simonnet G., Ancel C., Simonneaux V., Beltramo M., Bucher B., Sorg T., Meziane H., Schneider E., Petit-Demoulière B., Ilien B., Bihel* F., Simonin* F. (2017). Neuropharmacol. 118, 188-198.
- Neuropeptide-FF increases macrophage self-renewal and abrogates inflammation in adipose tissue. Waqas S.F.S., Hoang, A.C.; Lin Y.-T., Ampem, G., Azegrouz H., Balogh L., Thuróczy, J., Chen J.-C., Gerling I. C., Nam S., Lim J.-S., Martínez-Ibañez J., Real J. T., Paschke S., Quillet R., Ayachi S., Simonin F.; Schneider M., Brinkman J.A., Lamming D.W., Seroogy C. M., Röszer T. (2017). J. Clin. Invest. 127, 2842-2854
- GPR103-26RFa is a new pronociceptive system involved in neuroadaptive changes associated with chronic opioid administration and inflammatory pain. Ayachi S., Elhabazi K., Gerum M., Lecoz G.M., Drieu La Rochelle A., Zens J., Hugel S., Jhamandas J.H., Schmitt M.,Sorg T., Champy M.F., Meziane H., Petit-demoulière B., Tawfik L.,Shuster A.,Scherrer G., Kremer M., Wurtz X., Caussade F., Diop L., Darbaky Y., Bourguignon J.J., Bihel F. and Simonin F. (2022). Submitted
Webinar Registration link : wym-1654687397529
Mei LI, PhD, Group Leader IGBMC, Illkirch
Title of the presentation: Deciphering skin immune Network in mic
Summary: To illustrate a strong and long-lasting collaboration with iCS Department of genetic engineering and model validation service, Mei Li will give an overview on how to use mouse modelling system to acquire and advance the knowledge on skin immunity and inflammation and to identify therapeutic targets for inflammatory skin diseases
Publications made with iCS: Li, J., Leyva-Castillo, J. M., Hener, P., Eisenmann, A., Zaafouri, S., Jonca, N., et al. (2016). Counterregulation between thymic stromal lymphopoietin– and IL-23–driven immune axes shapes skin inflammation in mice with epidermal barrier defects. Journal of Allergy and Clinical Immunology, 0(0), 150–161.e13. http://doi.org/10.1016/j.jaci.2016.01.013
Luc DUPUIS, PhD, INSERM Research Director, Head of INSERM U1118
Title of the presentation : Understanding the pathophysiology of ALS and FTD related to FUS using mouse models
Summary: FUS is a major RNA binding protein involved in transcription, splicing and various steps of RNA lifecycle. FUS cytoplasmic aggregates are found in amyotrophic lateral sclerosis and fronto-temporal dementia, but their role in disease remained elusive. We generated various FUS mouse models allowing conditional cytoplasmic mislocalization of FUS, that illuminated the role of cytoplasmic FUS in neurons and skeletal muscle, and showed that timing and localization of cytoplasmic accumulation is critical for different symptoms of ALS and FTD.
Many mouse models in the last
ten years on various genes related to Charcot’s disease have been generated with iCS
A recent publication made with ICS : Scekic-Zahirovic, EMBO J, 2016; Scekic-Zahirovic, Acta Neuropathol, 2017; Picchiarelli, Nat Neuro 2019; Scekic-Zahirovic, Sanjuan Ruiz, Nat Comm 2021
Webinar Registration link : https://us06web.zoom.us/webinar/register/WN_2ApYQp_iTjiwED9Aqh5TZw
Gérard Gradwohl, PhD, Group Leader DR1 INSERM, IGBMC, Illkirch
Title of the presentation: Diversity of enteroendocrine cells and function of gut hormones in energy metabolism
Summary:In the first part of my presentation I will review our current knowledge of the diversity of rare intestinal cells called enteroendocrines cells (EECs). EECs sense nutrients in the gut lumen and subsequently secrete hormones that act locally or at distance to control metabolism. In the second part, I will describe the phenotype of mouse models designed to understand the pathophysiology of rare human monogenic diseases characterized by EECs failures and intestinal malabsorption.
Binnaz Yalcin, PhD, Group Leader, Inserm Unit 1231 Dijon
Title of the presentation: Deciphering neurodevelopmental anomalies in mice
Summary: I will divide my talk in two parts describing two key projects of my lab with ICS. First, I will talk about sex-specific differences when a genetic mutation is involved in brain development. Second, I will outline how dissecting the autism-associated 16p11.2 locus allowed us to identify multiple drivers in brain neuroanatomical phenotypes and unveil a new role for the major vault protein.
Brigitte KIEFFER, PhD, INSERM Research Director
Title of the Presentation: Receptors in brain circuits: where and how do they work?
Summary: We will present a number of knock-in mouse lines, which we have created together with the ICS. These lines have allowed the direct visualization of our receptors of interest in neurons and brain circuits, and further, the genetic manipulation of these receptors, and neurons expressing them, to understand their function in the brain.
Christine Petit, M.D, PhD, Institut Pasteur
Title of the Presentation: Towards Gene Therapy for Sensorineural Deafness
Thomas Rosahl, PhD, external in vivo pharmacology lead at MSD Research Laboratories, will show how the ICS phenotyping platforms contribute to the research carried out in his company; Thomas is a Senior Principal Scientist at merck, leading the MSD Research Laboratories collaboration with the ICS to phenotype Genetically Engineering Mouse models at a large scale using the various phenotyping platforms at the ICS.
Title of the presentation: Impact of GEM phenotyping at ICS for MSD Research Laboratories
Summary: For the last 18 years, Merck Research Laboratories has engaged in a collaboration with the ICS to phenotype Genetically Engineered mouse – and more recently rat – models. ICS has all phenotyping platforms under one roof, from GEM generation and gene expression analysis to validate novel GEM models, to behavior, cardio, metabolic, respiratory, histopathology and immunophenotyping. The presentations will highlight some vignettes on how ICS phenotyping impacted on the MRL drug discovery programs.
Françoise Piguet, PhD, researcher at the Institut du Cerveau et de la Moelle épinière (ICM), will present how ICS allowed her to collect the data necessary to prepare clinical trials for gene therapies. Françoise was previously a researcher at IGBMC using ICS platform and contracting punctually with ICS once she has joined the NEUROGENCELL team at ICM.
Title of the presentation: Gene therapy approaches for neurodegenerative and demyelinating diseases
Summary: Gene therapy approches to target either a specific gene or a metabolic pathway require proof of concept in several models and translational studies in rats and non human primates to develop a full set of data in order to prepare a clinical trial.
To celebrate the 20th anniversary, the ICS team will lead, be associated with or be part of the satellite events of the official ceremony on 17-18 November 2022.
ICS is meeting with ITI Neurostra to establish links and promote exchanges on behavioral phenotyping of mouse and rat models, particularly to list the expertise in Strasbourg and to discuss the technical developments proposed by ICS (Touchscreen and learning process, Live Mouse tracker and social behavior study, Digigait and locomotor behavior analysis by a machine-learning software, etc.).
Organisers: Benoit Petit-Demoulière (Head of Phenotyping department at ICS) and its colleagues (Hugues Jacobs, Fabrice Riet et Nicolas Torquet), Anne-Laurence Boutillier (DR CNRS, UMR 7364, Unistra) & Caroline Rouaux (Research Associate, INSERM, UMR_S 1118, Unistra)
To be part: the exchanges will take place at the CRBS auditorium (1 rue Eugène Boeckel, Strasbourg) will be conducted in French. The meeting is open for whom is concerned by the Neurobehavior research without registration to attend. The meeting will be held online in case the sanitary conditions would not allow to come together physically. Same date and same time