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A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.

Dubos A(1)(2)(3)(4), Meziane H(4), Iacono G(5), Curie A(6), Riet F(4), Martin C(7), Loaec N(8), Birling MC(4), Selloum M(4), Normand E(7)(9), Pavlovic G(4), Sorg T(4), Stunnenberg HG(5), Chelly J(1)(2)(3)(10), Humeau Y(7), Friocourt G(8), Herault Y(1)(2)(3)(4).
Hum Mol Genet 2018 Jun 15;27(12):2138-2153

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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Nguyen TL(1)(2)(3)(4)(5), Duchon A(1)(2)(3)(4), Manousopoulou A(6), Loaec N(5), Villiers B(5), Pani G(1)(2)(3)(4), Karatas M(7)(8), Mechling AE(8), Harsan LA(7)(8), Limanton E(9), Bazureau JP(9), Carreaux F(9), Garbis SD(10), Meijer L(11), Herault Y(12)(2)(3)(4).
Dis Model Mech 2018 Sep 27;11(9):pii: dmm035634

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Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.

Iacono G(1), Dubos A(2)(3)(4)(5), Meziane H(2), Benevento M(6)(7)(8), Habibi E(1), Mandoli A(1), Riet F(2), Selloum M(2), Feil R(9)(10), Zhou H(1)(7), Kleefstra T(7)(8), Kasri NN(6)(7)(8), van Bokhoven H(6)(7)(8), Herault Y(2)(3)(4)(5), Stunnenberg HG(1).
Nucleic Acids Res 2018 Jun 1;46(10):4950-4965

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Nox4 genetic inhibition in experimental hypertension and metabolic syndrome.

Bouabout G(1), Ayme-Dietrich E(2), Jacob H(1), Champy MF(1), Birling MC(1), Pavlovic G(1), Madeira L(2), Fertak LE(1), Petit-Demouliere B(1), Sorg T(1), Herault Y(1), Mudgett J(3), Monassier L(4).
Arch Cardiovasc Dis 2018 Jan;111(1):41-52

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Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.

Ung DC(1)(2), Iacono G(3), Meziane H(4), Blanchard E(1)(5)(6), Papon MA(1)(2), Selten M(7), van Rhijn JR(7), Montjean R(8)(9)(10)(11), Rucci J(8)(9)(10)(11), Martin S(12), Fleet A(13), Birling MC(4), Marouillat S(1)(2), Roepman R(14)(15), Selloum M(4), Lux A(4), Thepault RA(1)(2), Hamel P(13), Mittal K(16), Vincent JB(16), Dorseuil O(8)(9)(10)(11), Stunnenberg HG(3), Billuart P(8)(9)(10)(11), Nadif Kasri N(7)(14), Herault Y(4)(17)(18)(19)(20), Laumonnier F(1)(2)(6).
Mol Psychiatry 2018 May;23(5):1356-1367

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Synaptic dysfunction in amygdala in intellectual disorder models.

Aincy M(1), Meziane H(2), Herault Y(3), Humeau Y(4).
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jun 8;84(pt B):392-397

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Translating molecular advances in Down syndrome and Fragile X syndrome into therapies.

Faundez V(1), De Toma I(2), Bardoni B(3), Bartesaghi R(4), Nizetic D(5), de la Torre R(6), Cohen Kadosh R(7), Herault Y(8), Dierssen M(9), Potier MC(10); Down Syndrome and Other Genetic Developmental Disorders ECNP Network.
Eur Neuropsychopharmacol 2018 Jun;28(6):675-690

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