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Departments

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Non-invasive blood pressure

Purpose

Determination of systolic blood pressure and heart rate in conscious mice by tail-cuff method.

Strain background references

Equipment

Two apparatus of BP-2000 seriesII 6 channels (Visitech Systems, Apex, North Carolina, USA)

Recommendations

Number of animals: 9 mice/gender/genotype . Maximum age : 8 weeks

Electrocardiography (ECG)

Purpose

Evaluation of the electrical activity of the heart in anesthetized mice

Sample test results

Equipment

Electrocardiogram ISO DAM8 amplifier (World Precision Instruments, USA) and Analogic-numeric conversion box (ITF16A/D converter, EMKA technologies, USA)

Recommendations

Number of animals: 7-9 mice/gender/genotype

Echocardiography

Purpose

Echocardiography is considered the first-line diagnostic test, from which subsequent imaging or interventions can be recommended.

The Vevo 2100 High-Frequency Ultrasound Systems have been developed specifically for use in small animal imaging and are ideally suited for mouse or rat echocardiography. With center operating frequencies ranging from 15MHz to 50MHz one imaging system can be used to assess cardiac function from embryo to adult in many commonly used small animal models. 

Strain background references

Equipment

Vevo imaging System (VISUALSONICS, Amsterdam, The Netherlands).

Recommendations

Number of animals: 7-9 mice/gender/genotype

Telemetry

Purpose

Telemetry blood pressure and heart rate: continuous recording of the systolic, diastolic and mean blood pressure and heart rate in conscious mice.

Telemetry EKG: continuous recording of electrocardiogram in conscious mice.

Strain background references

Equipment

24 channels Data Sciences International acquisition system with 24 RPC-1 telemetric probe

The radio-telemetry system consists in implants and receiver: telemetry implants for small animals transmit data to receiver via AM radio waves.

The receiver is the RPC-1 receiver - DSI

-The Data Exchange Matrix - DSI
-The Computer (Dell) - DSI
-The Data Acquisition and Analysis System (Dataquest) - DSI

Telemetry blood pressure and heart rate

The implantable telemetry, PA-C10 Device (transmitter), for blood pressure and heart rate - DSI


Telemetry EKG

The implantable telemetry devices (transmitters) – DSI ETA-F20 Device for Electrocardiogram

Recommendations

Number of animals: 8-10 mice/gender/genotype

Optimal body weight: 30g

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