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A constitutive Knock-In is a model engineered to carry a cDNA sequence coding for a protein in a selected locus.

  • 1. The protein coding sequence will be expressed under the control of the endogenous promoter.

  • 2. The protein coding sequence is expected to be expressed with the same pattern than the endogenous gene.

  • 3. This modification will also lead to the inactivation of the endogenous allele.

ICS expertise:

  • Our experience in the design of such models will improve the chance to reproduce the pattern and expression level of the corresponding endogenous allele.

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