The Flex technology developed by Professor Pierre Chambon and Dr. Norbert Ghyselinck at the IGBMC is the unique available technique allowing the creation of inducible mutations in the animals.
A recombinase catalyzed one-way genetic switch enables the expression of a modified allele in a specific biological system, organ or cell population. The wild type allele is expressed in the rest of the animal.
Schnutgen F., Doerflinger N., Calleja C., Wendling O., Chambon P., Ghyselinck N.B.
Nat Biotechnol 2003 May;21(5):562-5
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